CSF1R LIGANDS IL-34 AND CSF1 ARE DIFFERENTIALLY REQUIRED FOR MICROGLIA DEVELOPMENT AND MAINTENANCE IN WHITE AND GRAY MATTER BRAIN REGIONS

CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions

Microglia are specialized brain macrophages that play numerous roles in tissue homeostasis and response to injury.Colony stimulating factor 1 receptor (CSF1R) is a receptor tyrosine kinase required for the development, maintenance, and proliferation of microglia.Here we show that in adult mice peripheral dosing of function-blocking antibodies to De

read more

Multiple motors cooperate to establish and maintain acentrosomal spindle bipolarity in C. elegans oocyte meiosis

While centrosomes organize spindle poles during mitosis, oocyte meiosis can occur in their absence.Spindles in human oocytes frequently fail to maintain bipolarity and consequently undergo chromosome segregation errors, making it important to understand the mechanisms that promote acentrosomal spindle stability.To this end, we have optimized the au

read more

Study on the analysis method on ballistic performance of deterred propellant with large web size in large caliber artillery

As for the characteristics of combustibility of deterrent propellant with large web size which is used in large-caliber gun and interior ballistic performance, ORG CANNELLINI BEANS the combustion characteristics of deterrent propellant are obtained by using closed-bomb experiments.The combustion law of deterrent propellant and the classic interior

read more

Knowledge-Based Patient Screening for Rare and Emerging Infectious/Parasitic Diseases: A Case Study of Brucellosis and Murine Typhus

Many infectious and parasitic diseases, especially those newly emerging or reemerging, present a difficult diagnostic challenge because of their obscurity and low incidence.Important clues that could lead to an initial diagnosis are often overlooked, Incontinence Pants misinterpreted, not linked to a disease, or disregarded.We constructed a compute

read more

Older adults with dual sensory loss in rehabilitation show high functioning and may fare better than those with single sensory loss.

The population of older adults that have Dual Sensory Loss (DSL) is increasing, yet most research to date has focused on single sensory impairment and is inconclusive as to whether DSL is associated with worse impact on health and well-being over single sensory loss.The primary aim of this study was to characterize the health and functioning of com

read more